Dr Nicholas Rattray
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites
Area of Expertise
Lab has broad experience in
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Publications
- Does modified 5-item frailty index correlate with survival in oropharyngeal squamous cell carcinoma?
- Chmielecka Marta, Hurley Rhona, Slim Mohd Afid Mohd, Philp Nichola, Donachie Matthew, Horackiewicz Jan, McGovern Josh, Knight Katrina, Rattray Nicholas J W, Paterson Claire, Douglas Catriona M
- Head and Neck (2025)
- https://doi.org/10.1002/hed.70005
- Senescence cell induction methods display diverse metabolic reprogramming and reveal an underpinning serine/taurine reductive metabolic phenotype
- Berardi Domenica, Farrell Gillian, AlSultan Abdullah, McCulloch Ashley, Hall Nicole M, Pereira Sousa Rui Pedro, Jimenez Melanie, Selman Colin, Bellantuono Ilaria, Johnson Caroline H, Rattray Zahra, Rattray Nicholas J W
- Aging Cell Vol 24 (2025)
- https://doi.org/10.1111/acel.70127
- A geroscience response to cancellation of the UK’s medicines repurposing programme : challenges and opportunities
- Rattray Nicholas, Rattray Zahra, Bellantuono Ilaria, Lasky-Su Jessica, Cox Lynne
- The Lancet Healthy Longevity (2025)
- https://doi.org/10.1016/j.lanhl.2025.100744
- The application of omics technologies in Type II diabetes mellitus research
- Al Sultan Abdullah, Rattray Zahra, Rattray Nicholas J W
- Current Diabetes Reviews Vol 21 (2025)
- https://doi.org/10.2174/0115733998362669250424162654
- An expert consensus statement on biomarkers of ageing for use in intervention studies
- Perri Giorgia, French Chloe, Agostinis-Sobrinho César, Anand Atul, Antarianto Radiana Dhewayani, Arai Yasumichi, Baur Joseph A, Cauli Omar, Clivaz-Duc Morgane, Colloca Giuseppe, Demetriades Constantinos, de Lucia Chiara, Di Gessa Giorgio, Diniz Breno S, Dotchin Catherine L, Eaglestone Gillian, Elliott Bradley T, Espeland Mark A, Ferrucci Luigi, Fisher James, Grammatopoulos Dimitris K, Hardiany Novi S, Hassan-Smith Zaki, Hastings Waylon J, Jain Swati, Joshi Peter K, Katsila Theodora, Kemp Graham J, Khaiyat Omid A, Lamming Dudley W, Gallegos Jose Lara, Madeo Frank, Maier Andrea B, Martin-Ruiz Carmen, Martins Ian J, Mathers John C, Mattin Lewis R, Merchant Reshma A, Moskalev Alexey, Neytchev Ognian, Ni Lochlainn Mary, Owen Claire M, Phillips Stuart M, Pratt Jedd, Prokopidis Konstantinos, Rattray Nicholas J W, Rúa-Alonso María, Schomburg Lutz, Scott David, Shyam Sangeetha, Sillanpää Elina, Tan Michelle M C, Teh Ruth, Tobin Stephanie W, Vila-Chã Carolina J, Vorluni Luigi, Weber Daniela, Welch Ailsa, Wilson Daisy, Wilson Thomas, Zhao Tongbiao, Philippou Elena, Korolchuk Viktor I, Shannon Oliver M
- The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences Vol 80 (2025)
- https://doi.org/10.1093/gerona/glae297
- Application News: A biological model of the ageing metabolome reveals potentially clinically relevant biomarkers
- Armitage Emily, Berardi Domenica, Barnes Alan, Loftus Neil, Farrell Gillian, Al Sultan Abdullah, McCulloch Ashley, Rattray Zahra, Rattray Nicholas
- (2025)
Professional Activities
- SIPBS Open Doors
- Contributor
- 14/6/2025
- PhD Viva Examiner (Internal)
- Examiner
- 12/6/2025
- Translating biological models of the ageing into clinically relevant biomarkers
- Speaker
- 10/6/2025
- Data & AI Meetup: Life Sciences
- Speaker
- 2/4/2025
- Podcast on Mentorship Across Borders
- Speaker
- 10/12/2024
- Defining Biomarkers of Surgical Frailty (ACORN WELCOME LEAP)
- Speaker
- 2/12/2024
Projects
- DTP 2224 University of Strathclyde | Almawazini, Mohammad
- Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator) Almawazini, Mohammad (Research Co-investigator)
- 01-Jan-2025 - 01-Jan-2028
- CAMS Industry Partnership
- Rattray, Nicholas (Principal Investigator)
- 01-Jan-2024 - 31-Jan-2027
- Frailty (eFI JARSS NHS Monies)
- Rattray, Nicholas (Principal Investigator)
- 01-Jan-2024 - 31-Jan-2028
- Dxcover Brain Cancer Analysis
- Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator)
- 01-Jan-2024 - 30-Jan-2025
- Dementia biomarker detection using resonant Raman spectroscopy at point of need.
- Rattray, Nicholas (Principal Investigator)
- 01-Jan-2024 - 31-Jan-2025
- iCAL Strathclyde CDT - Industry Contribution
- Rattray, Nicholas (Principal Investigator)
- 01-Jan-2023 - 30-Jan-2026
Contact
Dr
Nicholas
Rattray
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: nicholas.rattray@strath.ac.uk
Tel: 548 2012