Professor Glenn Burley
Pure and Applied Chemistry
Personal statement
Glenn A. Burley (GAB) is Professor of Chemical Biology at the University of Strathclyde. The main focus of GAB’s research programme is the development of molecular probes to further our understanding of processes involved in gene expression. GAB was awarded a Bachelor of Medicinal Chemistry (Hon. I) and a PhD in Organic Chemistry from the University of Wollongong, Australia. GAB was a post-doctoral fellow in the Fullerene Science Centre at the University of Sussex (2001-2003) and an Alexander von Humboldt Fellow at the University of Munich (2004-2006). GAB began his independent career as an EPSRC Advanced Fellow in 2007 at the University of Leicester, before moving to Strathclyde in 2011.
Publications
- Expanding the reaction toolbox for nanoscale direct-to-biology PROTAC synthesis and biological evaluation
- Stevens Rebecca, Shrives Harry J, Cryan Jenni, Klimaszewska Diana, Stacey Peter, Burley Glenn A, Harling John D, Battersby David J, Miah Afjal H
- RSC Medicinal Chemistry Vol 16, pp. 1141-1150 (2025)
- https://doi.org/10.1039/D4MD00760C
- Quantifying antibody binding : techniques and therapeutic implications
- Lodge James, Kajtar Lewis, Duxbury Rachel, Hall David, Burley Glenn A, Cordy Joanna, Yates James WT, Rattray Zahra
- mAbs Vol 17 (2025)
- https://doi.org/10.1080/19420862.2025.2459795
- Factors to consider for synthesis in 1536-well plates - an amide coupling case study for PROTAC synthesis
- Stevens Rebecca, Palmer Harry E P, Miah Afjal H, Burley Glenn A
- Journal of Organic Chemistry Vol 90, pp. 2192-2200 (2025)
- https://doi.org/10.1021/acs.joc.4c02456
- Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2
- Salihovic Admir, Ascham Alex, Rosenqvist Petja S, Taladriz-Sender Andrea, Hoskisson Paul A, Hodgson David R W, Grogan Gideon, Burley Glenn A
- Chemical Science Vol 16, pp. 1302-1307 (2024)
- https://doi.org/10.1039/D4SC07521H
- Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling
- Halford-McGuff John M, Richardson Thomas M, McKay Aidan P, Peschke Frederik, Burley Glenn A, Watson Allan J B
- Beilstein Journal of Organic Chemistry Vol 20, pp. 3198-3204 (2024)
- https://doi.org/10.3762/bjoc.20.265
- Assessing the manufacturability and critical quality attribute profiles of anti-IL-8 immunoglobulin G mutant variants
- Armstrong Georgina Bethany, Burley Glenn A, Lewis William, Rattray Zahra
- Molecular Pharmaceutics Vol 21, pp. 6423–6432 (2024)
- https://doi.org/10.1021/acs.molpharmaceut.4c01010
Research Interests
The Burley group (www.burleylabs.co.uk) applies a problem-based ethos that utilizes synthetic organic chemistry, biocatalysisand physical organic chemistry to explore regulatory mechanisms of transcription and RNA processing. A second research area of interest is the development of bio-orthogonal chemistries to prepare bioconjugates for cell selective drug delivery.
Professional Activities
- LINXS Chemistry of Life Meeting
- Speaker
- 18/10/2024
- Mechanism inspired ynamine modification of biomolecules
- Speaker
- 9/6/2024
- Invited speaker - School of Chemistry
- Speaker
- 8/5/2024
- 57th Bürgenstock Conference on Stereochemistry
- Participant
- 28/4/2024
- Next-generation oligonucleotide therapies: synthesis, target engagement and chemical biology
- Speaker
- 18/4/2024
- Cpi Innovation Services Limited (External organisation)
- Advisor
- 1/7/2023
Projects
- Development of sensitive and analytically robust biosensor biochips for respiratory virus detection
- Corrigan, Damion (Principal Investigator) Burley, Glenn (Co-investigator)
- 07-Jan-2024 - 06-Jan-2028
- High-Throughput PROTAC Synthesis to Target Synthetic Lethality in Epigenetics
- Burley, Glenn (Principal Investigator)
- 01-Jan-2024 - 31-Jan-2024
- Industrial CASE Account - University of Strathclyde 2024 | Salvadori, Irene
- Rattray, Zahra (Principal Investigator) Burley, Glenn (Co-investigator) Salvadori, Irene (Research Co-investigator)
- 01-Jan-2024 - 01-Jan-2028
- Industrial CASE Account - University of Strathclyde 2024 | Paszczuk, Lauren
- Burley, Glenn (Principal Investigator) Rattray, Zahra (Co-investigator) Paszczuk, Lauren (Research Co-investigator)
- 01-Jan-2024 - 01-Jan-2028
- Predicting and controlling High Order Structures for the development of more effective and safer therapeutic peptides (ICASE)
- Rattray, Zahra (Principal Investigator) Burley, Glenn (Co-investigator)
- 01-Jan-2024 - 30-Jan-2028
- GLAS-CYTO: AN INTEGRATED FACILITY FOR THE BIOPHYSICAL ANALYSIS OF CELLULAR INTERACTIONS
- Burley, Glenn (Principal Investigator) Chamberlain, Luke (Co-investigator) Chow, Shiao (Co-investigator) Corrigan, Damion (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Faulds, Karen (Co-investigator) Jamieson, Craig (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator) Taladriz Sender, Andrea (Research Co-investigator)
- 01-Jan-2024 - 31-Jan-2025
Contact
Professor
Glenn
Burley
Pure and Applied Chemistry
Email: glenn.burley@strath.ac.uk
Tel: 548 2792